gastrin-6

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Ligands
gastrin-6 (Human)

GtoPdb Ligand ID: 3557

Compound class: Endogenous peptide in human, mouse or rat

Comment: Gastrin-6 is the smallest circulating bioactive gastrin in humans. It is found in sulfated and nonsulfated forms, with sulphation increasing efficacy [1].

Species: Human

Summary
Biological activity
References
Structure
Similar ligands

Bioactivity Comments
Gastrin-6 has a higher potency but a lower efficacy than gastrin-17 [1]. Reported EC₅₀ values for maximum acid output are 43, 24, and 25 pM, for gastrin-17, sulfated gastrin-6, and nonsulfated gastrin-6 respectively [1]. We have been unable to find provenanced affinity data for gastrin-6 vs. the cholecystokinin B receptor.

Bioactivity Comments

Gastrin-6 has a higher potency but a lower efficacy than gastrin-17 [1]. Reported EC₅₀ values for maximum acid output are 43, 24, and 25 pM, for gastrin-17, sulfated gastrin-6, and nonsulfated gastrin-6 respectively [1].
We have been unable to find provenanced affinity data for gastrin-6 vs. the cholecystokinin B receptor.