Synonyms: pentazocine | WIN-20228
(-)-pentazocine is an approved drug (FDA (1967))
Compound class:
Synthetic organic
Comment: (-)-pentazocine is one of the two enantiomers in the approved drug pentazocine. (-)-pentazocine is a κ-opioid receptor agonist, while (+)-pentazocine exhibits ten-fold greater affinity for the σ receptor. Pentazocine is a mixed agonist-antagonist opioid pain medication. It is postulated that pentazocine behaves as an agonist at the κ and σ opioid receptors and has weak antagonistic action at the μ receptor.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: pentazocine |
|
Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1967)) |
International Nonproprietary Names | |
INN number | INN |
1674 | pentazocine |
Synonyms |
pentazocine | WIN-20228 |
Database Links | |
Specialist databases | |
GPCRdb Ligand | (-)-pentazocine |
Other databases | |
BindingDB Ligand | 50001028 |
CAS Registry No. | 359-83-1 (source: Scifinder) |
ChEMBL Ligand | CHEMBL560 |
DrugBank Ligand | DB00652 |
GtoPdb PubChem SID | 135650806 |
PubChem CID | 441278 |
Search Google for chemical match using the InChIKey | VOKSWYLNZZRQPF-GDIGMMSISA-N |
Search Google for chemicals with the same backbone | VOKSWYLNZZRQPF |
Search PubMed clinical trials | pentazocine |
Search PubMed titles | pentazocine |
Search PubMed titles/abstracts | pentazocine |
UniChem Compound Search for chemical match using the InChIKey | VOKSWYLNZZRQPF-GDIGMMSISA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VOKSWYLNZZRQPF-GDIGMMSISA-N |
Wikipedia | Pentazocine |