ChEMBL ligand: CHEMBL560
δ receptor/Delta-type opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa-type opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] Kappa-type opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu-type opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu-type opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu-type opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma non-opioid intracellular receptor 1 in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] sigma non-opioid intracellular receptor 1/Sigma non-opioid intracellular receptor 1 in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] Sigma non-opioid intracellular receptor 1 in Guinea pig [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	6.74	pKi	180	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	7.3	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [125I]OXY from human delta opioid receptor expressed in CHO cells	B	7.31	pKi	49	nM	Ki	J Med Chem (2010) 53: 1392-1396 [PMID:20055417]
κ receptor/Kappa-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	8.6	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]; J Pharmacol Exp Ther (1997) 282: 676-84 [PMID:9262330]
ChEMBL	Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cells	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2010) 53: 1392-1396 [PMID:20055417]
Kappa-type opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting	B	8.44	pKi	3.6	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
μ receptor/Mu-type opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	8.16	pKi	6.9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	-	-	8.4	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cells	B	8.41	pKi	3.9	nM	Ki	J Med Chem (2010) 53: 1392-1396 [PMID:20055417]
μ receptor/Mu-type opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity against opioid receptor mu using [3H]-DAMGO as radioligand.	B	7.89	pKi	13	nM	Ki	J Med Chem (1992) 35: 2812-2818 [PMID:1322987]
Mu-type opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting	B	8.34	pKi	4.6	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
sigma non-opioid intracellular receptor 1/Sigma non-opioid intracellular receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Tested for binding affinity against sigma receptors	B	6.96	pKi	110	nM	Ki	J Med Chem (1994) 37: 1214-1219 [PMID:8164264]
ChEMBL	Binding affinity measured on Sigma receptor type 1 from guinea pig brain membranes using [3H]pentazocine as radioligand.	B	7.08	pKi	83.1	nM	Ki	J Med Chem (1995) 38: 2978-2985 [PMID:7636860]
ChEMBL	Binding affinity was measured on Sigma receptor type 1 using [3H]- pentazocine as radioligand	B	7.08	pKi	83.1	nM	Ki	J Med Chem (1995) 38: 2986-2989 [PMID:7636861]
ChEMBL	Affinity against Sigma opioid receptor type 1 using [3H](+)-pentazocine in guinea pig brain membranes	B	7.08	pKi	83.1	nM	Ki	J Med Chem (1999) 42: 4621-4629 [PMID:10579824]
ChEMBL	Affinity against Sigma opioid receptor type 2 using [3H]- DTG in rat liver membranes	B	7.44	pKi	36.5	nM	Ki	J Med Chem (1999) 42: 4621-4629 [PMID:10579824]
sigma non-opioid intracellular receptor 1/Sigma non-opioid intracellular receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL	Binding affinity at Sigma receptor type 2 on rat liver membranes receptor by [3H]DTG displacement.	B	7.44	pKi	36.5	nM	Ki	J Med Chem (1995) 38: 2978-2985 [PMID:7636860]
ChEMBL	Binding affinity was measured on Sigma receptor type 2 using [3H]- DTG as radioligand	B	7.44	pKi	36.5	nM	Ki	J Med Chem (1995) 38: 2986-2989 [PMID:7636861]
ChEMBL	Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate	B	7.8	pKi	16	nM	Ki	J Med Chem (2010) 53: 1392-1396 [PMID:20055417]
ChEMBL	Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation counting	B	7.82	pKi	15	nM	Ki	ACS Med Chem Lett (2011) 2: 834-839 [PMID:24900272]
ChEMBL	Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes	B	6.77	pIC50	170	nM	IC50	J Med Chem (2000) 43: 177-189 [PMID:10649973]
ChEMBL	Binding affinity towards Sigma receptor type 2 in whole rat brain homogenates except cerebellum using radioligand ([3H]DTG) binding assay.	B	7.54	pIC50	29	nM	IC50	J Med Chem (1995) 38: 2009-2017 [PMID:7783132]
ChEMBL	Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.	B	8.05	pIC50	8.9	nM	IC50	J Med Chem (1995) 38: 2009-2017 [PMID:7783132]
Sigma non-opioid intracellular receptor 1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492]
ChEMBL	Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane	B	7.08	pKi	83.4	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5238-5241 [PMID:18774292]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]