GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

duvakitug   Click here for help

GtoPdb Ligand ID: 14420

Synonyms: TEV-48574 | TEV48574
Immunopharmacology Ligand
Compound class: Antibody
Comment: Duvakitug (TEV-48574) is a fully human IgG1λ monoclonal antibody that targets TL1A (TNFSF15) [6]. TL1A signalling through its receptor, death receptor 3 (DR3) modulates inflammatory responses and is implicated in profibrotic pathways [1,3-4]. Based on amino acid sequence matches to the heavy and light chain variable regions of duvakitug we suspect this is antibody clone 320-587 in patent US10138296B2 [5].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TL1A Hs Antibody Binding 10.4 pKd - 5
⤷ pKd 10.4 (Kd 4.1x10-11 M) [5]