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lorigerlimab   Click here for help

GtoPdb Ligand ID: 14407

Synonyms: MGD-019 | MGD019
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lorigerlimab (MGD019) is a tetravalent bispecific IgG4 antibody that simultaneously targets CTLA-4 and PD-1, developed by MacroGenics using DART® technology [1]. It was proposed to reverse the immunosuppressive and immune evasion activities of these two immune checkpoint proteins and thereby enhance the efficacy of tumour-infiltrating lymphocytes in the tumour microenvironment.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11771 lorigerlimab
Synonyms Click here for help
MGD-019 | MGD019
Database Links Click here for help
Search PubMed clinical trials lorigerlimab
Search PubMed titles lorigerlimab
Search PubMed titles/abstracts lorigerlimab