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SK5527   Click here for help

GtoPdb Ligand ID: 14285

Synonyms: compound 33 [PMID: 41252673] | SK-5527
Compound class: Synthetic organic
Comment: SK5527 is an Aurora kinase A (AURKA) PROTAC degrader [1]. SK5527 was developed as a progression from the previously reported MK-5108-thalidomide cereblon E3-recruiting AURKA PROTAC SK2188 [2], which was reported to induce loss of the neuroblastoma-related oncogenic transcription factor MYCN (MYCN), but whose pharmacokinetics precluded in vivo activity; AURKA normally protects MYCN from proteasomal degradation by the SCFFBXW7 E3 ubiquitin ligase.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 140.58
Molecular weight 848.36
XLogP 1.78
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=CC(=NN1)NC2=CC=C(C(=N2)CC3(CCN(CC3)CC4=CC=CC(=C4F)Cl)C(=O)N5CCC(CC5)(CN6CCN(CC6)C7=CC=C(C=N7)N8CCC(=O)NC8=O)F)F
Isomeric SMILES FC1=CC=C(NC2=NNC(C)=C2)N=C1CC3(C(N4CCC(CC4)(F)CN5CCN(CC5)C6=CC=C(N7C(NC(CC7)=O)=O)C=N6)=O)CCN(CC8=C(F)C(Cl)=CC=C8)CC3
InChI InChI=1S/C42H49ClF3N11O3/c1-28-23-35(52-51-28)49-34-7-6-32(44)33(48-34)24-41(10-15-53(16-11-41)26-29-3-2-4-31(43)38(29)45)39(59)56-17-12-42(46,13-18-56)27-54-19-21-55(22-20-54)36-8-5-30(25-47-36)57-14-9-37(58)50-40(57)60/h2-8,23,25H,9-22,24,26-27H2,1H3,(H,50,58,60)(H2,48,49,51,52)
InChI Key HIODCMZUTOISEE-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
Synonyms Click here for help
compound 33 [PMID: 41252673] | SK-5527
Database Links Click here for help
Search Google for chemical match using the InChIKey HIODCMZUTOISEE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HIODCMZUTOISEE
UniChem Compound Search for chemical match using the InChIKey HIODCMZUTOISEE-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey HIODCMZUTOISEE-UHFFFAOYSA-N