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rosnilimab   Click here for help

GtoPdb Ligand ID: 14271

Synonyms: ANB-030 | ANB030
Immunopharmacology Ligand
Compound class: Antibody
Comment: Rosnilimab (ANB-030; AnaptysBio) is a programmed cell death 1 (PD-1) monoclonal antibody that activates the PD-1 signaling pathway as a mechanism to suppress pathogenic T cell-mediated immune activation for the treatment of autoimmune disorders [1,3-4]. PD-1 agonist monoclonals are claimed in AnaptysBio patent US20220235132 [2]. Peptide sequences for 3.7C6 (APE12095) clones in this patent match the complementarity-determining region (CDR) sequences that form the antigen-binding site of rosnilimab, as annotated by IMGT.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
The biological data curated here is derived from clones 3.7C6 (APE12095) in the AnaptysBio patent [2].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 (CD279) Hs Antibody Agonist 10.3 pKd - 2
⤷ pKd 10.3 (Kd 5.1x10-11 M) [2]
Description: Binding affinity determined by SPR
programmed cell death 1 (CD279) Monkey Antibody Agonist 6.6 pKd - 2
⤷ pKd 6.6 (Kd 2.44x10-7 M) [2]
Description: Binding affinity determined by SPR
programmed cell death 1 (CD279) Hs Antibody Agonist ~6.3 pIC50 - 2
⤷ pIC50 ~6.3 (IC50 ~5x10-7 M) [2]
Description: Potency determined in a competition binding assay displacing human PD-L1