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odronextamab   Click here for help

GtoPdb Ligand ID: 12690

Synonyms: Ordspono® | REGN-1979 | REGN1979
Approved drug
odronextamab is an approved drug (EMA (2024))
Compound class: Antibody
Comment: Odronextamab (REGN1979) is a fully human CD3ε/CD20 bispecific IgG4-based antibody that redirects CD3+ cytotoxic T cells to selectively destroy CD20+ve malignant B cells [3]. Fc-mediated effector function has been minimised by modification of the IgG4 Fc domain.
Bioactivity Comments
Induces target-dependent lysis of CD20+ve lymphoma cells by human and cynomolgus T cells in vitro (EC50 15-84 pM), and demonstrates anti-tumour activity in in vivo B cell lymphoma models [3].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD20 (membrane-spanning 4-domains, subfamily A, member 1) Hs Antibody Binding - - - 3
⤷ [3]