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dostarlimab   Click here for help

GtoPdb Ligand ID: 11518

Synonyms: ANB-011 | dostarlimab-gxly | Jemperli® | TSR-042 | WBP-285
Approved drug Immunopharmacology Ligand
dostarlimab is an approved drug (EMA & FDA (2021))
Compound class: Antibody
Comment: Dostarlimab is a humanized, IgG4κ programmed cell death 1 (PD-1) blocking monoclonal antibody from GlaxoSmithKline.
Bioactivity Comments
A meeting abstract indicates that dostarlimab has high affinity for both human and cynomolgus monkey PD-1, but does not cross-react with the mouse orthologue, and that it inhibits the interaction of both PD-L1 and PD-L2 with PD-1.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 (CD279) Primary target of this compound Hs Antibody Binding - - - 1
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