Synonyms: TTT3002
Compound class:
Synthetic organic
Comment: TTT-3002 is an experimental indolocarbazole kinase inhibitor. It was originally reported as a LRRK2 inhibitor (including activity against the G2019S and R1441C mutations) [3]. Subsequent analysis revealed that TTT-3002 overcomes activating and drug resistance mutations in FLT3 in acute myeloid leukemia cells [2] and is active against FLT3-associated leukemias in vitro and in vivo [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Synonyms |
TTT3002 |
Database Links | |
Specialist databases | |
Reactome Drug | R-ALL-9702989 |
Reactome Reaction | R-HSA-9702508, R-HSA-9695828 |
Other databases | |
ChEBI | CHEBI:88219 |
GtoPdb PubChem SID | 434122194 |
PubChem CID | 92136143 |
Search Google for chemical match using the InChIKey | DCAYZGCTSXLIHO-FYCNXDEQSA-N |
Search Google for chemicals with the same backbone | DCAYZGCTSXLIHO |
UniChem Compound Search for chemical match using the InChIKey | DCAYZGCTSXLIHO-FYCNXDEQSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DCAYZGCTSXLIHO-FYCNXDEQSA-N |