AM-6120

Ligand id: 10119

Name: AM-6120

Classification
Compound class Peptide or derivative
Synonyms
AM6120 | peptide 41 [PMID: 30346167]
Comments
AM-6120 is a peptidic voltage-gated sodium channel blocker with the sequence Glu-[Pra1;Nle6;Ala12;5-BrW24;Glu28]JzTx-V(1-29), where JzTx-V is a sodium channel inhibitor isolated from tarantula venom [2]. JzTx-V inhibits NaV1.7 activity by interacting with the second voltage sensor domain of the NaV1.7 pore forming α-subunit and thereby holding the ion channel in a closed conformation, but its action is non-selective [1].
Database Links
GtoPdb PubChem SID 381118829