panulisib | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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panulisib
Ligand Activity Charts

panulisib [Ligand Id: 9916] activity data from GtoPdb

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activin A receptor type IL in Human [GtoPdb: 1784] [UniProtKB: P37023] There should be some charts here, you may need to enable JavaScript!
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
activin A receptor type IL in Human [GtoPdb: 1784] [UniProtKB: P37023]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	7.33	pIC50	47	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	8.36	pIC50	4.4	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	8.66	pIC50	2.2	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	6.75	pIC50	176	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	8.4	pIC50	4	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	Using a radiometric protein kinase (³³PanQinase activity) assay.	-	6.69	pIC50	203	nM	IC50	Mol Cancer Ther (2015) 14: 1095-106 [PMID:25700704]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.