6-Hydroxy-5,7-dimethoxyflavone [Ligand Id: 9878] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL464108 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815] | ||||||||
| GtoPdb | Inhibition of PDE4A1A activity in vitro. | - | 5.12 | pIC50 | 7510 | nM | IC50 | Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828] |
| phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343] | ||||||||
| GtoPdb | Inhibition of PDE4B2 activity in vitro. | - | 5.07 | pIC50 | 8580 | nM | IC50 | Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828] |
| phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] | ||||||||
| GtoPdb | Inhibition of PDE4C1 activity in vitro. | - | 5.76 | pIC50 | 1750 | nM | IC50 | Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828] |
| phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] | ||||||||
| GtoPdb | Inhibition of PDE4D2 activity in vitro. | - | 5.45 | pIC50 | 3530 | nM | IC50 | Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
