UFM24 [Ligand Id: 9878] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL464108
  • phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815]
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  • phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
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  • phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
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  • phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 4A in Human [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb Inhibition of PDE4A1A activity in vitro. - 5.12 pIC50 7510 nM IC50 Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828]
phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
GtoPdb Inhibition of PDE4B2 activity in vitro. - 5.07 pIC50 8580 nM IC50 Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828]
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb Inhibition of PDE4C1 activity in vitro. - 5.76 pIC50 1750 nM IC50 Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb Inhibition of PDE4D2 activity in vitro. - 5.45 pIC50 3530 nM IC50 Free Radic Biol Med (2017) 106: 379-392 [PMID:28263828]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]