CBS-3595 [Ligand Id: 9610] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL432798
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
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  • phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in HEK293 cells by patch clamp method B 4.54 pIC50 28600 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb In vitro determination. - 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
ChEMBL Inhibition of p38alpha (unknown origin) B 6.3 pIC50 500 nM IC50 J Med Chem (2022) 65: 15993-16032 [PMID:36490325]
ChEMBL Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay B 6.73 pIC50 188 nM IC50 J Med Chem (2011) 54: 3283-3297 [PMID:21449619]
phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
GtoPdb Determined against the PDE4B1 splice variant. - 5.72 pIC50 1900 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb Determined against the PDE4D3 splice variant. - 6.1 pIC50 800 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]