CBS-3595 [Ligand Id: 9610] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL432798
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
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  • phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in HEK293 cells by patch clamp method B 4.54 pIC50 28600 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
GtoPdb In vitro determination. - 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
ChEMBL Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay B 6.73 pIC50 188 nM IC50 J. Med. Chem. (2011) 54: 3283-3297 [PMID:21449619]
phosphodiesterase 4B in Human [GtoPdb: 1301] [UniProtKB: Q07343]
GtoPdb Determined against the PDE4B1 splice variant. - 5.72 pIC50 1900 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb Determined against the PDE4D3 splice variant. - 6.1 pIC50 800 nM IC50 J Med Chem (2017) 60: 5290-5305 [PMID:28613871]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]