ChEMBL ligand: CHEMBL375312
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha-1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase beta-1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL	Inhibition of GST-tagged LRRK2 (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblotting analysis	B	4	pIC50	>100000	nM	IC50	Biochem J (2009) 424: 47-60 [PMID:19740074]
ChEMBL	Inhibition of GST-tagged LRRK2 G2019S mutant (1326 to 2527 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblotting analysis	B	4	pIC50	>100000	nM	IC50	Biochem J (2009) 424: 47-60 [PMID:19740074]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL	Affinity Phenotypic Cellular interaction (Western Blot (phosphorylation of MYPT at Thr850 in HEK293 cells)) EUB0000134b ROCK1	B	5	pIC50	<10000	nM	IC50	Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomics Library wave 3
GtoPdb	-	-	7.85	pIC50	14	nM	IC50	J Med Chem (2007) 50: 6-9 [PMID:17201405]
ChEMBL	Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM	B	7.85	pIC50	14	nM	IC50	J Med Chem (2007) 50: 6-9 [PMID:17201405]
ChEMBL	Affinity Biochemical interaction (Scintillation Proximity Assay (SPA)) EUB0000134b ROCK1	B	7.85	pIC50	14	nM	IC50	Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL	Affinity Phenotypic Cellular interaction (Western Blot (phosphorylation of MYPT at Thr850 in HEK293 cells)) EUB0000134b ROCK2	B	5	pIC50	<10000	nM	IC50	Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL	Affinity Biochemical interaction (Enzymatic inhibition assay (100 µM ATP)) EUB0000134b ROCK2	B	7.2	pIC50	63	nM	IC50	Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL	Inhibition of His6-tagged ROCK2 (2 to 543 residues) (unknown origin) using peptide as substrate incubated for 15 mins in presence of ATP by immunoblotting analysis	B	7.2	pIC50	63	nM	IC50	Biochem J (2009) 424: 47-60 [PMID:19740074]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL	Inhibition of RSK1	B	6.11	pIC50	780	nM	IC50	J Med Chem (2007) 50: 6-9 [PMID:17201405]
GtoPdb	-	-	6.11	pIC50	780	nM	IC50	J Med Chem (2007) 50: 6-9 [PMID:17201405]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL	Inhibition of p70S6K	B	5.71	pIC50	1940	nM	IC50	J Med Chem (2007) 50: 6-9 [PMID:17201405]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]