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ChEMBL ligand: CHEMBL3039530 (LAS-100977, LAS100977, Abediterol) |
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1
CHEMBL3039530_lig_chart_1
β1-adrenoceptor
Human
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2
CHEMBL3039530_lig_chart_2
β2-adrenoceptor
Human
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3
CHEMBL3039530_lig_chart_3
β3-adrenoceptor
Human
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | Membrane radioligand displacement assay using [3H]CGP12177 as tracer. | - | 7.44 | pIC50 | 36.2 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
β2-adrenoceptor in Human [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
GtoPdb | Membrane radioligand displacement assay using [3H]CGP12177 as tracer. | - | 9.22 | pIC50 | 0.6 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
GtoPdb | - | - | 5.52 | pIC50 | 3001 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]