CGI560 [Ligand Id: 9264] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2057914
  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL Inhibition of human BTK by enzymatic assay B 6.4 pIC50 400 nM IC50 J. Med. Chem. (2012) 55: 4539-4550 [PMID:22394077]
ChEMBL Inhibition of C-terminal V5-His6 tagged human full-length Btk expressed in Sf9 cells by Lanthascreen assay B 6.4 pIC50 400 nM IC50 MedChemComm (2019) 10: 294-299
GtoPdb - - 6.4 pIC50 400 nM IC50 J Med Chem (2012) 55: 4539-50 [PMID:22394077]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]