compstatin [Ligand Id: 9218] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL266963 (Compstatin)
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  • complement factor B/Complement factor B in Human [ChEMBL: CHEMBL5731] [GtoPdb: 2339] [UniProtKB: P00751]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Complement C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4917] [UniProtKB: P01024]
ChEMBL Binding affinity to complement component C3 in human plasma by isothermal titration calorimetry B 5.89 pKd 1300 nM Kd J Biol Chem (2007) 282: 29241-29247 [PMID:17684013]
ChEMBL Inhibition of C3 (unknown origin)-binding to convertase of classical pathway by hemolytic assay B 4.2 pIC50 63000 nM IC50 J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
ChEMBL Inhibition of C3 (unknown origin)-binding to convertase of alternative pathway by hemolytic assay B 4.92 pIC50 12000 nM IC50 J Med Chem (2018) 61: 3253-3276 [PMID:28977749]
complement factor B/Complement factor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5731] [GtoPdb: 2339] [UniProtKB: P00751]
ChEMBL Inhibition of human C3/C5 convertase assessed as inhibition of C3 cleavage B 4.92 pIC50 12000 nM IC50 J Med Chem (2009) 52: 6042-6052 [PMID:19743866]
ChEMBL Inhibition of C3 convertase B 5.47 pIC50 3400 nM IC50 Bioorg Med Chem (2008) 16: 1562-1595 [PMID:18053726]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]