PSB-0963 [Ligand Id: 9023] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL608559 (PSB-0963)
Created with Highcharts 10.3.3ValuesChart context menu5`-nucleotidasepKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961]
Created with Highcharts 10.3.3ValuesChart context menuEctonucleoside triphosphate diphosphohydrolase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Ectonucleoside triphosphate diphosphohydrolase 3 in Human [ChEMBL: CHEMBL5897] [UniProtKB: O75355]
Created with Highcharts 10.3.3ValuesChart context menuEctonucleoside triphosphate diphosphohydrolase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • P2Y2 receptor/Purinergic receptor P2Y2 in Human [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
Created with Highcharts 10.3.3ValuesChart context menuPurinergic receptor P2Y2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
Created with Highcharts 10.3.3ValuesChart context menuPyrimidinergic receptor P2Y4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371]
Created with Highcharts 10.3.3ValuesChart context menuPyrimidinergic receptor P2Y6pKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ecto-5'-Nucleotidase/5`-nucleotidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075214] [GtoPdb: 1232] [UniProtKB: P21588]
GtoPdb - - 6.82 pKi 150 nM Ki J Med Chem (2010) 53: 2076-86 [PMID:20146483]
ChEMBL Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method B 6.82 pKi 150 nM Ki J Med Chem (2010) 53: 2076-2086 [PMID:20146483]
ectonucleoside triphosphate diphosphohydrolase 1/Ectonucleoside triphosphate diphosphohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5722] [GtoPdb: 2888] [UniProtKB: P49961]
ChEMBL Inhibition of human NTPdase1 by capillary electrophoresis method B 5.59 pKi 2590 nM Ki J Med Chem (2010) 53: 2076-2086 [PMID:20146483]
GtoPdb - - 5.59 pKi 2590 nM Ki J Med Chem (2010) 53: 2076-86 [PMID:20146483]
Ectonucleoside triphosphate diphosphohydrolase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5897] [UniProtKB: O75355]
ChEMBL Inhibition of human NTPdase3 by capillary electrophoresis method B 4.22 pKi >60000 nM Ki J Med Chem (2010) 53: 2076-2086 [PMID:20146483]
P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231]
ChEMBL Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 10000 nM IC50 J Med Chem (2010) 53: 2076-2086 [PMID:20146483]
P2Y4 receptor/Pyrimidinergic receptor P2Y4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2123] [GtoPdb: 325] [UniProtKB: P51582]
ChEMBL Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 >10000 nM IC50 J Med Chem (2010) 53: 2076-2086 [PMID:20146483]
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3543] [GtoPdb: 326] [UniProtKB: Q63371]
ChEMBL Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization F 5 pIC50 >10000 nM IC50 J Med Chem (2010) 53: 2076-2086 [PMID:20146483]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]