compound 9 [PMID: 23472952] [Ligand Id: 9017] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2326089
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089]
ChEMBL Inhibition of human arginase 1 transfected in CHO cells assessed as inhibition of urea formation after 24 hrs by spectrophotometric analysis B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (2013) 56: 2568-2580 [PMID:23472952]
GtoPdb - - 6.65 pIC50 223 nM IC50 J Med Chem (2013) 56: 2568-80 [PMID:23472952]
ChEMBL Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis B 6.65 pIC50 223 nM IC50 J. Med. Chem. (2013) 56: 2568-2580 [PMID:23472952]
ChEMBL Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay B 7.74 pIC50 18 nM IC50 ACS Med Chem Lett (2020) 11: 582-588 [PMID:32292567]
Arginase II/Arginase-2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540]
GtoPdb - - 6.29 pIC50 509 nM IC50 J Med Chem (2013) 56: 2568-80 [PMID:23472952]
ChEMBL Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis B 6.29 pIC50 509 nM IC50 J. Med. Chem. (2013) 56: 2568-2580 [PMID:23472952]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]