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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 354 | 14q24.1 | ARG2 | arginase 2 | |
Mouse | - | 354 | 12 C3 | Arg2 | arginase type II | |
Rat | - | 354 | 6q24 | Arg2 | arginase 2 |
Previous and Unofficial Names |
AII type II arginase | arginase 2 | kidney-type arginase | non-hepatic arginase | Mitochondrial arginase |
Database Links | |
Alphafold | P78540 (Hs), O08691 (Mm), O08701 (Rn) |
BRENDA | 3.5.3.1 |
ChEMBL Target | CHEMBL1795148 (Hs) |
Ensembl Gene | ENSG00000081181 (Hs), ENSMUSG00000021125 (Mm), ENSRNOG00000053811 (Rn) |
Entrez Gene | 384 (Hs), 11847 (Mm), 29215 (Rn) |
Human Protein Atlas | ENSG00000081181 (Hs) |
KEGG Enzyme | 3.5.3.1 |
KEGG Gene | hsa:384 (Hs), mmu:11847 (Mm), rno:29215 (Rn) |
OMIM | 107830 (Hs) |
Pharos | P78540 (Hs) |
SynPHARM | 83384 (in complex with compound 9 [PMID: 23472952]) |
UniProtKB | P78540 (Hs), O08691 (Mm), O08701 (Rn) |
Wikipedia | ARG2 (Hs) |
Selected 3D Structures | |||||||||||||
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Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
The role of ARG2 in immuno-oncology is reviewed in [1]. |
Immuno Process Associations | ||
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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]
2. Colleluori DM, Ash DE. (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry, 40 (31): 9356-62. [PMID:11478904]
3. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem, 56 (6): 2568-80. [PMID:23472952]
Arginase: Arginase II. Last modified on 16/03/2017. Accessed on 02/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1245.