AMG319 [Ligand Id: 8917] activity data from GtoPdb

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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Human
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Human
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Human
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 4.48 pIC50 33000 nM IC50 J Med Chem (2015) 58: 480-511 [PMID:25469863]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 5.57 pIC50 2700 nM IC50 J Med Chem (2015) 58: 480-511 [PMID:25469863]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta in Human [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb - - 7.74 pIC50 18 nM IC50 J Med Chem (2015) 58: 480-511 [PMID:25469863]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma in Human [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb - - 6.07 pIC50 850 nM IC50 J Med Chem (2015) 58: 480-511 [PMID:25469863]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.