compound 39 [PMID: 23623673] [Ligand Id: 8875] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2387503 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX2 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| Leukotriene C4 synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743183] [GtoPdb: 1391] [UniProtKB: Q16873] | ||||||||
| GtoPdb | - | - | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-78 [PMID:23623673] |
| ChEMBL | Inhibition of LTC4S (unknown origin) | B | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] | ||||||||
| ChEMBL | Inhibition of mPGES1-mediated PGE2 release in IL1alpha-stimulated human A549 cells | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| ChEMBL | Inhibition of mPGES1 (unknown origin)-mediated PGE2 synthesis transfected in HEK293 cells coexpressing COX1 using arachidonic acid as substrate preincubated for 30 mins prior to substrate addition measured after 60 mins by HTRF assay | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
| GtoPdb | - | - | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-78 [PMID:23623673] |
| CYP5A1/Thromboxane-A synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557] | ||||||||
| ChEMBL | Inhibition of thromboxane synthase (unknown origin) | B | 5.52 | pIC50 | >3000 | nM | IC50 | Bioorg Med Chem (2013) 21: 2868-2878 [PMID:23623673] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
