compound 33 [PMID: 19908842] [Ligand Id: 8874] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL578159
Created with Highcharts 10.3.3ValuesChart context menuCaspase-1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCathepsin LpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCathepsin SpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCathepsin ZpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuChymasepKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCruzipainpKd Trypanosoma cruzipKi Trypanosoma cruzipIC50 Trypanosoma cruzipEC50 Trypanosoma cruzi0246810Highcharts.com
  • cathepsin C/Dipeptidyl peptidase I in Human [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634]
Created with Highcharts 10.3.3ValuesChart context menuDipeptidyl peptidase IpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • kallikrein related peptidase 4/Kallikrein 4 in Human [ChEMBL: CHEMBL4446] [GtoPdb: 2374] [UniProtKB: Q9Y5K2]
Created with Highcharts 10.3.3ValuesChart context menuKallikrein 4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
Created with Highcharts 10.3.3ValuesChart context menuLeukocyte elastasepKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL Inhibition of human Caspase 1 B 4.79 pIC50 16218.1 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL Inhibition of human Cathepsin L B 5.1 pIC50 7943.28 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774]
ChEMBL Inhibition of human Cathepsin S B 4.57 pIC50 26915.35 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2]
ChEMBL Inhibition of human Cathepsin X/Z B 4.83 pIC50 14791.08 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946]
ChEMBL Inhibition of human Chymase B 4.05 pIC50 89125.09 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL Inhibition of Trypanosoma cruzi cruzain after 15 mins B 7.89 pIC50 13 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634]
ChEMBL Inhibition of human Cathepsin C B 5.16 pIC50 6918.31 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
kallikrein related peptidase 4/Kallikrein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4446] [GtoPdb: 2374] [UniProtKB: Q9Y5K2]
ChEMBL Inhibition of human Kallikrein 4 B 5.01 pIC50 9772.37 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
GtoPdb - - 5.01 pIC50 9772 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]
elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
ChEMBL Inhibition of human Elastase B 4.07 pIC50 85113.8 nM IC50 J Med Chem (2010) 53: 52-60 [PMID:19908842]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]