Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	333	9q21.33	CTSL	cathepsin L
Mouse	-	334	13 B3	Ctsl	cathepsin L

Previous and Unofficial Names

MEP | nackt | nkt | cathepsin L1 | fs | furless | Cat L | p39 cysteine proteinase

Database Links
Specialist databases
MEROPS	C01.032 (Hs)
Other databases
BRENDA	3.4.22.15
ChEMBL Target	CHEMBL3837 (Hs), CHEMBL5291 (Mm)
Ensembl Gene	ENSG00000135047 (Hs), ENSMUSG00000021477 (Mm)
Entrez Gene	1514 (Hs), 13039 (Mm)
Human Protein Atlas	ENSG00000135047 (Hs)
KEGG Enzyme	3.4.22.15
KEGG Gene	hsa:1514 (Hs), mmu:13039 (Mm)
OMIM	116880 (Hs)
Pharos	P07711 (Hs)
RefSeq Nucleotide	NM_001257971 (Hs), NM_001257972 (Hs), NM_001912 (Hs), NM_145918 (Hs), NM_009984 (Mm)
RefSeq Protein	NP_666023 (Hs), NP_001244901 (Hs), NP_001244900 (Hs), NP_001903 (Hs), NP_034114 (Mm)
UniProtKB	P07711 (Hs), P06797 (Mm)
Wikipedia	CTSL (Hs)

Enzyme Reaction
EC Number: 3.4.22.15

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference VBY-825 Hs Inhibition 9.6 pKi 1 ⤷ pKi 9.6 (Ki 2.5x10-10 M) [1] CAA0225 Rn Inhibition 8.7 pIC50 4 ⤷ pIC50 8.7 (IC50 1.9x10-9 M) [4] LHVS Hs Inhibition 8.1 pIC50 3 ⤷ pIC50 8.1 (IC50 7x10-9 M) [3] KGP94 Hs Inhibition 6.9 pIC50 2 ⤷ pIC50 6.9 (IC50 1.314x10-7 M) [2]
View species-specific inhibitor tables

Immunopharmacology Comments

Cathepsins B, H and L have become important therapeutic targets as their proteolytic activity has been implicated in several pathological inflammatory conditions, such as arthritis and periodontitis. Therefore, pharmacological inhibitors of these enzymes are in development as novel therapeutics.

Immuno Process Associations

Immuno Process:  Antigen presentation GO Annotations:  Associated to 2 GO processes GO:0019882 antigen processing and presentation TAS GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0002224 toll-like receptor signaling pathway TAS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002250 adaptive immune response IEP

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002250 adaptive immune response IEP

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0002224 toll-like receptor signaling pathway TAS

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes GO:0002224 toll-like receptor signaling pathway TAS