compound 8a [PMID: 23713581] [Ligand Id: 8856] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2396718
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
There should be some charts here, you may need to enable JavaScript!
  • protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2]
There should be some charts here, you may need to enable JavaScript!
  • RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
There should be some charts here, you may need to enable JavaScript!
  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
There should be some charts here, you may need to enable JavaScript!
  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
There should be some charts here, you may need to enable JavaScript!
  • Protein-tyrosine phosphatase 1C in Human [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
There should be some charts here, you may need to enable JavaScript!
  • Protein-tyrosine phosphatase 1E in Human [ChEMBL: CHEMBL2976] [UniProtKB: Q12923]
There should be some charts here, you may need to enable JavaScript!
  • Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [UniProtKB: Q06124]
There should be some charts here, you may need to enable JavaScript!
  • Protein-tyrosine phosphatase G1 in Human [ChEMBL: CHEMBL3236] [UniProtKB: Q05209]
There should be some charts here, you may need to enable JavaScript!
  • Protein-tyrosine phosphatase LC-PTP in Human [ChEMBL: CHEMBL2219] [UniProtKB: P35236]
There should be some charts here, you may need to enable JavaScript!
  • RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
There should be some charts here, you may need to enable JavaScript!
  • RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469]
There should be some charts here, you may need to enable JavaScript!
  • RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
There should be some charts here, you may need to enable JavaScript!
  • RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827]
There should be some charts here, you may need to enable JavaScript!
  • T-cell protein-tyrosine phosphatase in Human [ChEMBL: CHEMBL3807] [UniProtKB: P17706]
There should be some charts here, you may need to enable JavaScript!
  • Tyrosine-protein phosphatase non-receptor type 3 in Human [ChEMBL: CHEMBL2396509] [UniProtKB: P26045]
There should be some charts here, you may need to enable JavaScript!
  • Tyrosine-protein phosphatase non-receptor type 9 in Human [ChEMBL: CHEMBL6117] [UniProtKB: P43378]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dual specificity protein phosphatase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396507] [UniProtKB: Q9H1R2]
ChEMBL Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Dual specificity protein phosphatase 23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396506] [UniProtKB: Q9BVJ7]
ChEMBL Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.47 pIC50 3400 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL Inhibition of recombinant VHR (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.23 pIC50 5900 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2]
ChEMBL Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrophotometric analysis B 6.77 pIC50 171 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
GtoPdb - - 6.77 pIC50 171 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL Inhibition of recombinant CD45 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.49 pIC50 3200 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.47 pIC50 340 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.77 pIC50 1700 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
ChEMBL Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.04 pIC50 910 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923]
ChEMBL Inhibition of recombinant FAP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.41 pIC50 390 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [UniProtKB: Q06124]
ChEMBL Inhibition of recombinant SHP-2 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.25 pIC50 560 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase G1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3236] [UniProtKB: Q05209]
ChEMBL Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.1 pIC50 800 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236]
ChEMBL Inhibition of recombinant HEPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
ChEMBL Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.33 pIC50 470 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469]
ChEMBL Inhibition of recombinant PTPepsilon (unknown origin) using pNPP as substrate by spectrophotometric analysis B 4.6 pIC50 >25000 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
ChEMBL Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827]
GtoPdb - - 5.15 pIC50 7000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
ChEMBL Inhibition of recombinant PTPmu (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.15 pIC50 7000 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [UniProtKB: P17706]
ChEMBL Inhibition of recombinant TCPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 4.95 pIC50 11300 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Tyrosine-protein phosphatase non-receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396509] [UniProtKB: P26045]
ChEMBL Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.8 pIC50 1600 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]
Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378]
ChEMBL Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.23 pIC50 590 nM IC50 J. Med. Chem. (2013) 56: 4990-5008 [PMID:23713581]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]