compound 8a [PMID: 23713581] [Ligand Id: 8856] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2396718
Created with Highcharts 10.3.3ValuesChart context menuDual specificity protein phosphatase 15pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuDual specificity protein phosphatase 23pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Dual specificity protein phosphatase 3 in Human [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity protein phosphatase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2]
Created with Highcharts 10.3.3ValuesChart context menuHematopoietic cell protein-tyrosine phosphatase 70Z-PEPpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
Created with Highcharts 10.3.3ValuesChart context menuLeukocyte common antigenpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Low molecular weight phosphotyrosine protein phosphatase in Human [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
Created with Highcharts 10.3.3ValuesChart context menuLow molecular weight phosphotyrosine protein phosphatasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase 1BpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Protein-tyrosine phosphatase 1C in Human [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase 1CpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Protein-tyrosine phosphatase 1E in Human [ChEMBL: CHEMBL2976] [UniProtKB: Q12923]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase 1EpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase 2CpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Protein-tyrosine phosphatase G1 in Human [ChEMBL: CHEMBL3236] [UniProtKB: Q05209]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase G1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Protein-tyrosine phosphatase LC-PTP in Human [ChEMBL: CHEMBL2219] [UniProtKB: P35236]
Created with Highcharts 10.3.3ValuesChart context menuProtein-tyrosine phosphatase LC-PTPpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
Created with Highcharts 10.3.3ValuesChart context menuReceptor-type tyrosine-protein phosphatase betapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469]
Created with Highcharts 10.3.3ValuesChart context menuReceptor-type tyrosine-protein phosphatase epsilonpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
Created with Highcharts 10.3.3ValuesChart context menuReceptor-type tyrosine-protein phosphatase gammapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827]
Created with Highcharts 10.3.3ValuesChart context menuReceptor-type tyrosine-protein phosphatase mupKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706]
Created with Highcharts 10.3.3ValuesChart context menuT-cell protein-tyrosine phosphatasepKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Tyrosine-protein phosphatase non-receptor type 3 in Human [ChEMBL: CHEMBL2396509] [UniProtKB: P26045]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein phosphatase non-receptor type 3pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Tyrosine-protein phosphatase non-receptor type 9 in Human [ChEMBL: CHEMBL6117] [UniProtKB: P43378]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein phosphatase non-receptor type 9pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dual specificity protein phosphatase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396507] [UniProtKB: Q9H1R2]
ChEMBL Inhibition of recombinant VHX (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.54 pIC50 2900 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Dual specificity protein phosphatase 23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396506] [UniProtKB: Q9BVJ7]
ChEMBL Inhibition of recombinant VHZ (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.47 pIC50 3400 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452]
ChEMBL Inhibition of recombinant VHR (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.23 pIC50 5900 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2]
ChEMBL Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrophotometric analysis B 6.77 pIC50 171 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
GtoPdb - - 6.77 pIC50 171 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL Inhibition of recombinant CD45 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.49 pIC50 3200 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Low molecular weight phosphotyrosine protein phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4903] [UniProtKB: P24666]
ChEMBL Inhibition of recombinant LMWPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.47 pIC50 340 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.77 pIC50 1700 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3166] [UniProtKB: P29350]
ChEMBL Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.04 pIC50 910 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923]
ChEMBL Inhibition of recombinant FAP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.41 pIC50 390 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL Inhibition of recombinant SHP-2 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.25 pIC50 560 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase G1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3236] [UniProtKB: Q05209]
ChEMBL Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.1 pIC50 800 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236]
ChEMBL Inhibition of recombinant HEPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.52 pIC50 3000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type B/Receptor-type tyrosine-protein phosphatase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2706] [GtoPdb: 1851] [UniProtKB: P23467]
ChEMBL Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.33 pIC50 470 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469]
ChEMBL Inhibition of recombinant PTPepsilon (unknown origin) using pNPP as substrate by spectrophotometric analysis B 4.6 pIC50 >25000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
ChEMBL Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.4 pIC50 4000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827]
GtoPdb - - 5.15 pIC50 7000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
ChEMBL Inhibition of recombinant PTPmu (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.15 pIC50 7000 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706]
ChEMBL Inhibition of recombinant TCPTP (unknown origin) using pNPP as substrate by spectrophotometric analysis B 4.95 pIC50 11300 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Tyrosine-protein phosphatase non-receptor type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396509] [UniProtKB: P26045]
ChEMBL Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 5.8 pIC50 1600 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378]
ChEMBL Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis B 6.23 pIC50 590 nM IC50 J Med Chem (2013) 56: 4990-5008 [PMID:23713581]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]