RTP Type C | Receptor tyrosine phosphatase (RTP) family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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RTP Type C

  Target has curated data in GtoImmuPdb

Target id: 1852

Nomenclature: RTP Type C

Family: Receptor tyrosine phosphatase (RTP) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PTPRC protein tyrosine phosphatase, receptor type C
Mouse - - Ptprc protein tyrosine phosphatase
Rat - - Ptprc protein tyrosine phosphatase
Previous and Unofficial Names
RT7 | protein tyrosine phosphatase, receptor type, C | T200 glycoprotein | CD45 | gp180 | LCA | Ly-5 | Lyt-4 | T200 leukocyte common antigen | protein tyrosine phosphatase
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
galectin-1 {Sp: Human}
Comments: Putative endogenous ligand.
Immunopharmacology Comments
CD45 is a high molecular weight cell surface glycoprotein expressed by cells of hematopoietic origin. Alternate transcripts lead to expression of isoforms that differ in their extracellular (ligand binding) domain (potentially facilitating differential and/or cell type specific biological functions [1]) but all contain the same intracellular domain that has tyrosine phosphatase activity. In relation to immune pathology, a single report from 1992 notes the presence of autoantibodies to CD45 in serum from patients with active systemic lupus erythematosus [2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0043312 neutrophil degranulation TAS
click arrow to show/hide IEA associations
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 11 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030217 T cell differentiation ISS
GO:0042102 positive regulation of T cell proliferation ISS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0042098 T cell proliferation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 8 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0030183 B cell differentiation IEA
GO:0045577 regulation of B cell differentiation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 13 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042102 positive regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS
click arrow to show/hide IEA associations
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0045577 regulation of B cell differentiation IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
GO:0050855 regulation of B cell receptor signaling pathway IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 9 GO processes
GO:0002244 hematopoietic progenitor cell differentiation IMP
GO:0030217 T cell differentiation ISS
GO:0048539 bone marrow development IMP
click arrow to show/hide IEA associations
GO:0030183 B cell differentiation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045577 regulation of B cell differentiation IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 4 GO processes
GO:0042102 positive regulation of T cell proliferation ISS
click arrow to show/hide IEA associations
GO:0007159 leukocyte cell-cell adhesion IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 17 GO processes
GO:0030217 T cell differentiation ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
GO:0042102 positive regulation of T cell proliferation ISS
GO:0043312 neutrophil degranulation TAS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS
click arrow to show/hide IEA associations
GO:0030183 B cell differentiation IEA
GO:0042098 T cell proliferation IEA
GO:0045059 positive thymic T cell selection IEA
GO:0045060 negative thymic T cell selection IEA
GO:0045577 regulation of B cell differentiation IEA
GO:0045588 positive regulation of gamma-delta T cell differentiation IEA
GO:0046641 positive regulation of alpha-beta T cell proliferation IEA
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA
GO:0050855 regulation of B cell receptor signaling pathway IEA

References

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1. Dalchau R, Fabre JW. (1981) Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule. J. Exp. Med., 153 (4): 753-65. [PMID:6166706]

2. Winfield JB, Mimura T, Fernsten PD. (1992) Autoantibodies to CD45 in systemic lupus erythematosus. Int. J. Clin. Lab. Res., 21 (4): 292-5. [PMID:1534265]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type C. Last modified on 19/04/2017. Accessed on 16/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1852.