Top ▲

RTP Type C

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 1852

Nomenclature: RTP Type C

Family: Receptor tyrosine phosphatase (RTP) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1306 1q31.3-q32.1 PTPRC protein tyrosine phosphatase receptor type C
Mouse 1 1293 1 60.73 cM Ptprc protein tyrosine phosphatase receptor type C
Rat 1 1273 13q13 Ptprc protein tyrosine phosphatase, receptor type, C
Previous and Unofficial Names Click here for help
RT7 | protein tyrosine phosphatase, receptor type, C | T200 glycoprotein | CD45 | gp180 | LCA | Ly-5 | Lyt-4 | T200 leukocyte common antigen | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type C
Database Links Click here for help
Alphafold P08575 (Hs), P06800 (Mm), P04157 (Rn)
CATH/Gene3D 2.60.40.10, 3.90.190.10
ChEMBL Target CHEMBL3243 (Hs)
Ensembl Gene ENSG00000081237 (Hs), ENSMUSG00000026395 (Mm), ENSRNOG00000000655 (Rn)
Entrez Gene 5788 (Hs), 19264 (Mm), 24699 (Rn)
Human Protein Atlas ENSG00000081237 (Hs)
KEGG Gene hsa:5788 (Hs), mmu:19264 (Mm), rno:24699 (Rn)
OMIM 151460 (Hs)
Pharos P08575 (Hs)
UniProtKB P08575 (Hs), P06800 (Mm), P04157 (Rn)
Wikipedia PTPRC (Hs)
Natural/Endogenous Ligands Click here for help
galectin-1 {Sp: Human}
Comments: Putative endogenous ligand.
Immunopharmacology Comments
CD45 is a high molecular weight cell surface glycoprotein expressed by cells of hematopoietic origin. Alternate transcripts lead to expression of isoforms that differ in their extracellular (ligand binding) domain (potentially facilitating differential and/or cell type specific biological functions [1]) but all contain the same intracellular domain that has tyrosine phosphatase activity. In relation to immune pathology, a single report from 1992 notes the presence of autoantibodies to CD45 in serum from patients with active systemic lupus erythematosus [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling

References

Show »

1. Dalchau R, Fabre JW. (1981) Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule. J Exp Med, 153 (4): 753-65. [PMID:6166706]

2. Winfield JB, Mimura T, Fernsten PD. (1992) Autoantibodies to CD45 in systemic lupus erythematosus. Int J Clin Lab Res, 21 (4): 292-5. [PMID:1534265]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type C. Last modified on 19/04/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1852.