compound 1 [PMID: 21882820] [Ligand Id: 8831] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1403981
  • RTP Type C/Leukocyte common antigen in Human [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575]
ChEMBL Inhibition of CD45 expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay B 4.1 pIC50 79000 nM IC50 J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay B 4 pIC50 >100000 nM IC50 J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
RTP Type G/Receptor-type tyrosine-protein phosphatase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4905] [GtoPdb: 1856] [UniProtKB: P23470]
GtoPdb - - 5.6 pKi 2500 nM Ki J Med Chem (2011) 54: 6548-62 [PMID:21882820]
ChEMBL Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by Lineweaver-Burk plot B 5.6 pKi 2500 nM Ki J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET assay B 4.89 pIC50 12800 nM IC50 J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 20 mins by FRET assay B 5.59 pIC50 2600 nM IC50 J Med Chem (2011) 54: 6548-6562 [PMID:21882820]
ChEMBL Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincubated for 40 mins by FRET assay B 5.6 pIC50 2500 nM IC50 J Med Chem (2011) 54: 6548-6562 [PMID:21882820]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]