apstatin [Ligand Id: 8803] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL311875 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Leucine aminopeptidase 3/Leucine aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838] | ||||||||
| ChEMBL | Inhibition against Leucyl aminopeptidase from pig kidney. | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| X-prolyl aminopeptidase 1/Xaa-Pro aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3782] [GtoPdb: 1578] [UniProtKB: Q9NQW7] | ||||||||
| ChEMBL | Inhibition against cytosolic Aminopeptidase P from human heart. | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| GtoPdb | - | - | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| ChEMBL | Inhibition against Aminopeptidase P from human platelets. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4610] [GtoPdb: 1579] [UniProtKB: O43895] | ||||||||
| GtoPdb | - | - | 6.19 | pKi | 640 | nM | Ki | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| ChEMBL | Inhibition against membrane bound monkey aminopeptidase P | B | 5.21 | pIC50 | 6100 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| ChEMBL | Inhibition against membrane bound human aminopeptidase P | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| GtoPdb | - | - | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2970] [GtoPdb: 1579] [UniProtKB: Q99MA2] | ||||||||
| ChEMBL | Activity against membrane bound rat aminopeptidase P | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955] | ||||||||
| ChEMBL | Inhibition against Prolidase from pig kidney. | B | 5.31 | pIC50 | 4900 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
