apstatin [Ligand Id: 8803] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL311875 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Leucine aminopeptidase 3/Leucine aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838] | ||||||||
| ChEMBL | Inhibition against Leucyl aminopeptidase from pig kidney. | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| X-prolyl aminopeptidase 1/Xaa-Pro aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3782] [GtoPdb: 1578] [UniProtKB: Q9NQW7] | ||||||||
| ChEMBL | Inhibition against cytosolic Aminopeptidase P from human heart. | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| GtoPdb | - | - | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| ChEMBL | Inhibition against Aminopeptidase P from human platelets. | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| ChEMBL | Inhibition of 6-His tagged XPNPEP1 (unknown origin) expressed in Escherichia coli Rosetta DE3 cells using H-Lys(abz)-Pro-Pro-pNA as substrate incubated for 60 mins by fluorescence based analysis | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2023) 66: 2589-2607 [PMID:36724486] |
| X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4610] [GtoPdb: 1579] [UniProtKB: O43895] | ||||||||
| GtoPdb | - | - | 6.19 | pKi | 640 | nM | Ki | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| ChEMBL | Inhibition against membrane bound monkey aminopeptidase P | B | 5.21 | pIC50 | 6100 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| ChEMBL | Inhibition against membrane bound human aminopeptidase P | B | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| GtoPdb | - | - | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (1999) 42: 2394-402 [PMID:10395480] |
| X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2970] [GtoPdb: 1579] [UniProtKB: Q99MA2] | ||||||||
| ChEMBL | Activity against membrane bound rat aminopeptidase P | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
| peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955] | ||||||||
| ChEMBL | Inhibition of recombinant human PEPD using Ala-Pro as substrate assessed as alanine release by measuring increase in fluorescense signal by fluorescence based analysis | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (2023) 66: 2589-2607 [PMID:36724486] |
| ChEMBL | Inhibition against Prolidase from pig kidney. | B | 5.31 | pIC50 | 4900 | nM | IC50 | J Med Chem (1999) 42: 2394-2402 [PMID:10395480] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
