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X-prolyl aminopeptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 1579

Nomenclature: X-prolyl aminopeptidase 2

Family: M24: Methionyl aminopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 674 Xq26.1 XPNPEP2 X-prolyl aminopeptidase 2
Mouse - 674 X A3.2 Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Rat - 674 Xq36 Xpnpep2 X-prolyl aminopeptidase 2
Previous and Unofficial Names Click here for help
Aminopeptidase P 2 | membrane-bound X-prolyl aminopeptidase | mAPP | X-prolyl aminopeptidase (aminopeptidase P) 2
Database Links Click here for help
Specialist databases
MEROPS M24.005 (Hs)
Other databases
Alphafold O43895 (Hs), Q99MA2 (Rn)
BRENDA 3.4.11.9
CATH/Gene3D 3.40.350.10
ChEMBL Target CHEMBL4610 (Hs), CHEMBL2970 (Rn)
Ensembl Gene ENSG00000122121 (Hs), ENSMUSG00000037005 (Mm), ENSRNOG00000004009 (Rn)
Entrez Gene 7512 (Hs), 170745 (Mm), 117522 (Rn)
Human Protein Atlas ENSG00000122121 (Hs)
KEGG Enzyme 3.4.11.9
KEGG Gene hsa:7512 (Hs), mmu:170745 (Mm), rno:117522 (Rn)
OMIM 300145 (Hs)
Orphanet ORPHA281864 (Hs)
Pharos O43895 (Hs)
RefSeq Nucleotide NM_003399 (Hs), NM_133213 (Mm), NM_057155 (Rn)
RefSeq Protein NP_003390 (Hs), NP_573476 (Mm), NP_476496 (Rn)
UniProtKB O43895 (Hs), Q99MA2 (Rn)
Wikipedia XPNPEP2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.11.9

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
apstatin Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.2 pKi 1
⤷ pKi 6.2 (Ki 6.4x10-7 M) [1]
compound 6 [PMID: 10395480] Small molecule or natural product Hs Inhibition 6.6 pIC50 1
⤷ pIC50 6.6 (IC50 2.3x10-7 M) [1]
apstatin Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 5.5 pIC50 1
⤷ pIC50 5.5 (IC50 2.9x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Angioedema induced by ACE inhibitors, susceptibility to; AEACEI
Synonyms: Renin-angiotensin-aldosterone system-blocker-induced angioedema [Orphanet: ORPHA100057]
OMIM: 300909
Orphanet: ORPHA100057

References

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1. Maggiora LL, Orawski AT, Simmons WH. (1999) Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem, 42 (13): 2394-402. [PMID:10395480]

How to cite this page

M24: Methionyl aminopeptidase: X-prolyl aminopeptidase 2. Last modified on 18/09/2015. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1579.