illudalic acid [Ligand Id: 8770] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL506661 (Illudalic Acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity phosphatase 22 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3924] [UniProtKB: Q9NRW4] | ||||||||
| ChEMBL | Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| Dual specificity protein phosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2635] [UniProtKB: P51452] | ||||||||
| ChEMBL | Inhibition of VHR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type C/Leukocyte common antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243] [GtoPdb: 1852] [UniProtKB: P08575] | ||||||||
| ChEMBL | Inhibition of CD45 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 5 | pIC50 | 10000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] | ||||||||
| ChEMBL | Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4.54 | pIC50 | 29000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236] | ||||||||
| ChEMBL | Inhibition of HePTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type E/Receptor-type tyrosine-protein phosphatase epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4850] [GtoPdb: 1854] [UniProtKB: P23469] | ||||||||
| ChEMBL | Inhibition of PTPep (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| RTP Type F/Receptor-type tyrosine-protein phosphatase F (LAR) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3521] [GtoPdb: 1855] [UniProtKB: P10586] | ||||||||
| ChEMBL | Inhibition of LAR (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| ChEMBL | Inhibition of human recombinant LAR | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7399-7409 [PMID:18579388] |
| GtoPdb | Measured utilising purified recombinant LAR catalytic domain. | - | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7399-409 [PMID:18579388] |
| RTP Type M/Receptor-type tyrosine-protein phosphatase mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4661] [GtoPdb: 1860] [UniProtKB: P28827] | ||||||||
| ChEMBL | Inhibition of PTPmu (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
| protein tyrosine phosphatase non-receptor type 2/T-cell protein-tyrosine phosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3807] [GtoPdb: 3255] [UniProtKB: P17706] | ||||||||
| ChEMBL | Inhibition of TCPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2019) 82: 3386-3393 [PMID:31809044] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
