pexidartinib [Ligand Id: 8710] activity data from GtoPdb

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  • KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 KIT proto-oncogene, receptor tyrosine kinase Human
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  • colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 colony stimulating factor 1 receptor Human
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  • fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 fms related receptor tyrosine kinase 3 Human
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  • fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 fms related receptor tyrosine kinase 1 Human
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  • kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 kinase insert domain receptor Human
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  • neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 neurotrophic receptor tyrosine kinase 3 Human
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  • cyclin dependent kinase 19 in Human [GtoPdb: 1972] [UniProtKB: Q9BWU1]
  • This target only has 0 pki data point
  • 0
7 _lig_chart_7 cyclin dependent kinase 19 Human
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  • LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
  • This target only has 0 pki data point
  • 0
8 _lig_chart_8 LCK proto-oncogene, Src family tyrosine kinase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb - - 7.57 pIC50 <27 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333]
GtoPdb - - 7.89 pIC50 13 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb - - 6.8 pIC50 160 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
GtoPdb - - 6.06 pIC50 880 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb - - 6.36 pIC50 440 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
GtoPdb - - 6.05 pIC50 890 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
cyclin dependent kinase 19 in Human [GtoPdb: 1972] [UniProtKB: Q9BWU1]
GtoPdb - - 6.85 pIC50 140 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb - - 6.07 pIC50 860 nM IC50 N Engl J Med (2015) 373: 428-37 [PMID:26222558]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.