pexidartinib [Ligand Id: 8710] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| GtoPdb | - | - | 7.57 | pIC50 | <27 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| colony stimulating factor 1 receptor in Human [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| GtoPdb | - | - | 7.89 | pIC50 | 13 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | - | - | 6.8 | pIC50 | 160 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| GtoPdb | - | - | 6.06 | pIC50 | 880 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | - | - | 6.36 | pIC50 | 440 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| GtoPdb | - | - | 6.05 | pIC50 | 890 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| cyclin dependent kinase 19 in Human [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
| GtoPdb | - | - | 6.85 | pIC50 | 140 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
| LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| GtoPdb | - | - | 6.07 | pIC50 | 860 | nM | IC50 | N Engl J Med (2015) 373: 428-37 [PMID:26222558] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
