GSK9772 [Ligand Id: 8693] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL493241 (GSK9772) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] | ||||||||
| ChEMBL | Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domain | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2008) 51: 5758-5765 [PMID:18800767] |
| ChEMBL | Activation of LXRalpha by GAL4 reporter gene assay | B | 5.52 | pEC50 | 3000 | nM | EC50 | J Med Chem (2008) 51: 5758-5765 [PMID:18800767] |
| Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] | ||||||||
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2008) 51: 5758-65 [PMID:18800767] |
| ChEMBL | Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domain | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2008) 51: 5758-5765 [PMID:18800767] |
| ChEMBL | Activation of LXRbeta by GAL4 reporter gene assay | B | 5.52 | pEC50 | 3000 | nM | EC50 | J Med Chem (2008) 51: 5758-5765 [PMID:18800767] |
| Pregnane X receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3401] [GtoPdb: 606] [UniProtKB: O75469] | ||||||||
| ChEMBL | Inhibition of human PXR | B | 6.6 | pEC50 | 250 | nM | EC50 | J Med Chem (2008) 51: 5758-5765 [PMID:18800767] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
