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ChEMBL ligand: CHEMBL1229259 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
ChEMBL | Inhibition of factor 10a | B | 8.62 | pKi | 2.4 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] | ||||||||
ChEMBL | Inhibition of matriptase | B | 7.26 | pKi | 55 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
ChEMBL | Inhibition of plasma kallikrein | B | 8.08 | pKi | 8.3 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
ChEMBL | Inhibition of plasmin | B | 7.41 | pKi | 39 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Inhibition of thrombin | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235] | ||||||||
GtoPdb | - | - | 7.72 | pKi | 19 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839] |
ChEMBL | Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader analysis | B | 7.72 | pKi | 19 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
transmembrane serine protease 2/Transmembrane protease serine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393] | ||||||||
ChEMBL | Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescence plate reader analysis | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
GtoPdb | - | - | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839] |
transmembrane serine protease 6/Transmembrane protease serine 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795139] [GtoPdb: 2422] [UniProtKB: Q8IU80] | ||||||||
ChEMBL | Inhibition of matriptase 2 | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]