furin inhibitor peptide [Ligand Id: 8668] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL502642 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| furin, paired basic amino acid cleaving enzyme/Furin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958] | ||||||||
| ChEMBL | Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 7.64 | pKi | 23 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
| GtoPdb | - | - | 7.64 | pKi | 23 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
| proprotein convertase subtilisin/kexin type 6 in Human [GtoPdb: 2386] [UniProtKB: P29122] | ||||||||
| GtoPdb | - | - | 6.79 | pKi | 162 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
| proprotein convertase subtilisin/kexin type 6/Proprotein convertase subtilisin/kexin type 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5507] [GtoPdb: 2386] [UniProtKB: Q63415] | ||||||||
| ChEMBL | Inhibition of rat PACE4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.79 | pKi | 162 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
| proprotein convertase subtilisin/kexin type 4/Subtilisin/kexin type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4861] [GtoPdb: 2384] [UniProtKB: Q6UW60] | ||||||||
| ChEMBL | Inhibition of human recombinant PC4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.36 | pKi | 441 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
| GtoPdb | - | - | 6.36 | pKi | 441 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
| proprotein convertase subtilisin/kexin type 5/Subtilisin/kexin type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2826] [GtoPdb: 2385] [UniProtKB: Q92824] | ||||||||
| GtoPdb | - | - | 6.63 | pKi | 232 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
| ChEMBL | Inhibition of human recombinant PC5/6 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.63 | pKi | 232 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
| proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] | ||||||||
| GtoPdb | - | - | 6.82 | pKi | 152 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
| ChEMBL | Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.87 | pKi | 135 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
