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proprotein convertase subtilisin/kexin type 5

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Target not currently curated in GtoImmuPdb

Target id: 2385

Nomenclature: proprotein convertase subtilisin/kexin type 5

Family: S8: Subtilisin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1860 9q21.13 PCSK5 proprotein convertase subtilisin/kexin type 5
Mouse 1 1877 19 12.86 cM Pcsk5 proprotein convertase subtilisin/kexin type 5
Rat 1 1809 1q51 Pcsk5 proprotein convertase subtilisin/kexin type 5
Previous and Unofficial Names Click here for help
PC5/6A | PC5A | PC6 | proprotein convertase 5 | proprotein convertase 6 | SPC6
Database Links Click here for help
Specialist databases
MEROPS S08.076 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.6x10-9 M) [1]
furin inhibitor peptide Peptide Click here for species-specific activity table Hs Inhibition 6.6 pKi 2
pKi 6.6 (Ki 2.32x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0140447 cytokine precursor processing ISS

References

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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem, 53 (3): 1067-75. [PMID:20038105]

2. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem, 282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 5. Last modified on 28/07/2015. Accessed on 16/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2385.