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ChEMBL ligand: CHEMBL606201 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Fatty acid amide hydrolase in Human [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
GtoPdb | in vitro assay | - | 8.7 | pIC50 | 2 | nM | IC50 | Proc Natl Acad Sci USA (2009) 106: 20270-5 [PMID:19918051] |
Fatty acid amide hydrolase/Anandamide amidohydrolase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3455] [GtoPdb: 1400] [UniProtKB: O08914] | ||||||||
ChEMBL | Inhibition of FAAH in mouse brain membrane | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2010) 53: 1830-1842 [PMID:20099888] |
αβ-Hydrolase 6/Monoacylglycerol lipase ABHD6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5010] [GtoPdb: 2919] [UniProtKB: Q8R2Y0] | ||||||||
ChEMBL | Inhibition of ABHD6 in mouse brain membrane | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2010) 53: 1830-1842 [PMID:20099888] |
monoacylglycerol lipase/Monoglyceride lipase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4191] [GtoPdb: 1399] [UniProtKB: Q99685] | ||||||||
ChEMBL | Inhibition of human recombinant MAGL pre-incubated for 5 mins before MAGL substrate addition and further incubated for 10 mins | B | 6.69 | pIC50 | 204.5 | nM | IC50 | J Med Chem (2020) 63: 5783-5796 [PMID:32429662] |
GtoPdb | in vitro assay | - | 8.4 | pIC50 | 4 | nM | IC50 | Proc Natl Acad Sci USA (2009) 106: 20270-5 [PMID:19918051] |
monoacylglycerol lipase/Monoglyceride lipase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5774] [GtoPdb: 1399] [UniProtKB: O35678] | ||||||||
ChEMBL | Inhibition of MAGL in mouse brain membrane | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2010) 53: 1830-1842 [PMID:20099888] |
Neuropathy target esterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259506] [UniProtKB: Q3TRM4] | ||||||||
ChEMBL | Inhibition of NTE in mouse brain membrane | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2010) 53: 1830-1842 [PMID:20099888] |
acyloxyacyl hydrolase in Human [GtoPdb: 2873] [UniProtKB: P28039] | ||||||||
GtoPdb | - | - | 7.36 | pIC50 | 44 | nM | IC50 | Nat Chem Biol (2014) 10: 656-63 [PMID:24997602] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]