compound 10l [PMID: 24556381] [Ligand Id: 8603] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3125351
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
Created with Highcharts 10.3.3ValuesChart context menuAcetylcholinesterasepKd Electrophorus electricuspKi Electrophorus electricuspIC50 Electrophorus electricuspEC50 Electrophorus electricus012345Highcharts.com
  • elastase, neutrophil expressed/Leukocyte elastase in Human [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
Created with Highcharts 10.3.3ValuesChart context menuLeukocyte elastasepKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
Created with Highcharts 10.3.3ValuesChart context menuThrombinpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • carboxyl ester lipase in Pig [GtoPdb: 2872]
Created with Highcharts 10.3.3ValuesChart context menucarboxyl ester lipasepKd PigpKi PigpIC50 PigpEC50 Pig0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE B 4.64 pIC50 22900 nM IC50 Bioorg Med Chem Lett (2014) 24: 1545-1549 [PMID:24556381]
elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246]
GtoPdb - - 6.2 pIC50 630 nM IC50 Bioorg Med Chem Lett (2014) 24: 1545-9 [PMID:24556381]
ChEMBL Inhibition of human leukocyte elastase B 6.2 pIC50 630 nM IC50 Bioorg Med Chem Lett (2014) 24: 1545-1549 [PMID:24556381]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL Inhibition of human thrombin using H-D-Phe-L-Pip-Arg-para-nitroanilide as substrate after 5 mins B 4.52 pIC50 >=30000 nM IC50 Bioorg Med Chem Lett (2014) 24: 1545-1549 [PMID:24556381]
carboxyl ester lipase in Pig [GtoPdb: 2872]
GtoPdb - - 5.7 pIC50 1980 nM IC50 Bioorg Med Chem Lett (2014) 24: 1545-9 [PMID:24556381]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]