ML381 [Ligand Id: 8591] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3185781
  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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  • M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 5 pKi >10000 nM Ki ChemMedChem (2014) 9: 1677-82 [PMID:24692176]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 4.52 pKi >30000 nM Ki ChemMedChem (2014) 9: 1677-82 [PMID:24692176]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 4.52 pKi >30000 nM Ki ChemMedChem (2014) 9: 1677-82 [PMID:24692176]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 4.52 pKi <30000 nM Ki ChemMedChem (2014) 9: 1677-82 [PMID:24692176]
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912]
GtoPdb - - 6.3 pKi - - - ChemMedChem (2014) 9: 1677-82 [PMID:24692176]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]