ChEMBL ligand: CHEMBL518924 (Amd070, Amd 070, AMD070, AMD-070, AMD11070, AMD-11070, Cxcr4 inhibitor x4p-001, Mavorixafor, X4p001, X 4P-001, X4P-001)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
CCR1/C-C chemokine receptor type 1 in Human [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246] There should be some charts here, you may need to enable JavaScript!
CCR2/C-C chemokine receptor type 2 in Human [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597] There should be some charts here, you may need to enable JavaScript!
CCR4/C-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679] There should be some charts here, you may need to enable JavaScript!
CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] There should be some charts here, you may need to enable JavaScript!
CXCR4/C-X-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
CXCR1/Interleukin-8 receptor A in Human [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] There should be some charts here, you may need to enable JavaScript!
CXCR2/Interleukin-8 receptor B in Human [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Inhibition of alpha 2A adrenergic receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
CCR1/C-C chemokine receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
ChEMBL	Displacement of radiolabeled MIP1alpha from CCR1 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
ChEMBL	Displacement of radiolabeled MCP1 from CCR2b receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR4/C-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679]
ChEMBL	Displacement of radiolabeled TARC from CCR4 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL	Displacement of radiolabeled MIP1beta from CCR5 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
GtoPdb	Assay using 125I-SDF-1α as tracer, in Cf2Th cells expressing hCXCR4.	-	7.96	pKi	11	nM	Ki	Mol Pharmacol (2008) 74: 1485-95 [PMID:18768385]
ChEMBL	Antagonist activity at CXCR4 in human PBMC assessed as inhibition of HIV-1 3B infection	B	7.52	pIC50	30	nM	IC50	ACS Med Chem Lett (2013) 4: 1025-1030 [PMID:24936240]
ChEMBL	Displacement of [125I]SDF-1-alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation counting	B	7.89	pIC50	13	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
GtoPdb	Displacement of [125I]SDF-1α binding from CXCR4 in human CEM-CCRF cells by liquid scintillation counting.	-	7.89	pIC50	13	nM	IC50	J Med Chem (2010) 53: 3376-88 [PMID:20297846]
ChEMBL	Antagonist activity at CXCR4 receptor in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed by SDF-1alpha addition and monitered for 90 sec	F	8.29	pIC50	5.18	nM	IC50	ACS Med Chem Lett (2021) 12: 1605-1612 [PMID:34676043]
ChEMBL	Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDS1alpha-induced calcium flux pretreated for 25 mins followed by SDS1alpha addition measured for 90 secs by calcium-dye based assay	F	8.3	pIC50	5	nM	IC50	ACS Med Chem Lett (2018) 9: 446-451 [PMID:29795757]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Inhibition of dopamine D2 receptor (unknown origin)	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024]
ChEMBL	Displacement of radiolabeled IL8 from CXCR1 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025]
ChEMBL	Displacement of radiolabeled IL8 from CXCR2 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Inhibition of mu opioid receptor (unknown origin)	B	4.92	pIC50	12000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Inhibition of M2 mAChR receptor (unknown origin)	B	5.12	pIC50	7500	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Inhibition of alpha7 nicotinic acetylcholine receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]