compound 11 [PMID: 16413183] [Ligand Id: 8493] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL206454 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2034-6 [PMID:16413183] |
| ChEMBL | Binding affinity to plasma kallikrein | B | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2034-2036 [PMID:16413183] |
| coagulation factor VII in Human [GtoPdb: 2363] [UniProtKB: P08709] | ||||||||
| GtoPdb | Ki calculated from fold selectivity for KLKB1. | - | 7 | pKi | ~100 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2034-6 [PMID:16413183] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
