tepotinib [Ligand Id: 8293] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| GtoPdb | Measured in a flash-plate assay using recombinant human c-Met kinase domain and a biotinylated peptide substrate. | - | 8.52 | pIC50 | 3 | nM | IC50 | Clin Cancer Res (2013) 19: 2941-51 [PMID:23553846] |
| interleukin 1 receptor associated kinase 4 in Human [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| GtoPdb | Determined by NanoBRET assay | - | 6.33 | pIC50 | 469 | nM | IC50 | Nat Biotechnol (2026) null: null [PMID:42010121] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
