WH-4-023 [Ligand Id: 8068] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL213100
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
  • This target only has 0 pki data point
  • 0
1 CHEMBL213100_lig_chart_1 MAP kinase p38 alpha Human
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
  • This target only has 0 pki data point
  • 0
2 CHEMBL213100_lig_chart_2 Tyrosine-protein kinase LCK Human
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
  • This target only has 0 pki data point
  • 0
3 CHEMBL213100_lig_chart_3 Tyrosine-protein kinase SRC Human
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
  • This target only has 0 pki data point
  • 0
4 CHEMBL213100_lig_chart_4 Vascular endothelial growth factor receptor 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha B 5.89 pIC50 1300 nM IC50 J. Med. Chem. (2006) 49: 4981-4991 [PMID:16884310]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Inhibition of Lck in presence of 0.5 uM ATP by HTRF kinase assay B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2006) 49: 4981-4991 [PMID:16884310]
GtoPdb - - 8.7 pIC50 2 nM IC50 J Med Chem (2006) 49: 4981-91 [PMID:16884310]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb - - 8.22 pIC50 6 nM IC50 J Med Chem (2006) 49: 4981-91 [PMID:16884310]
ChEMBL Inhibition of Src B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2006) 49: 4981-4991 [PMID:16884310]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR B 6.19 pIC50 640 nM IC50 J. Med. Chem. (2006) 49: 4981-4991 [PMID:16884310]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]