ralimetinib [Ligand Id: 7959] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2364626 (LSN-2322600 FREE BASE, LSN2322600 FREE BASE, Ly-2228820, LY-2228820, LY2228820, LY22288220, Ralimetinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 14 in Human [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 179-83 [PMID:18039577] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| mitogen-activated protein kinase 11 in Human [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| GtoPdb | Inhibitor potency for EGFR with gatekeeper mutation T790M | - | 5.22 | pIC50 | 6060 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| GtoPdb | Inhibitor potency for WT EGFR | - | 6.74 | pIC50 | 180 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
| GtoPdb | Inhibitor potency for EGFRG719C | - | 7.96 | pIC50 | 11 | nM | IC50 | Cell Chem Biol (2023) 30: 1211-1222.e5 [PMID:37827156] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
