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ChEMBL ligand: CHEMBL1230065 (Bms-582949, Ps-540446, BMS-582949, PS-540446) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins | B | 7.89 | pIC50 | 13 | nM | IC50 | J. Med. Chem. (2010) 53: 6629-6639 [PMID:20804198] |
ChEMBL | Inhibition of P38alpha MAPK (unknown origin) | B | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2019) 182: 111624-111624 [PMID:31445234] |
GtoPdb | - | - | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2010) 53: 6629-39 [PMID:20804198] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
ChEMBL | Inhibition of p38beta (unknown origin) | B | 7.21 | pIC50 | 62 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4120-4126 [PMID:23746475] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]