purvalanol B [Ligand Id: 7806] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23254 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cdc2 in Patiria pectinifera (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5124] [UniProtKB: Q17066] | ||||||||
| ChEMBL | Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 1.5 mM [gamma32P]ATP | B | 6.6 | pIC50 | 250 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 150 M [gamma32P]ATP | B | 7.3 | pIC50 | 50 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 2/CDK2/Cyclin A2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of recombinant CDK2/CycA (unknown origin) | B | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2022) 240: 114603-114603 [PMID:35868123] |
| Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae cdc28 | B | 5.92 | pIC50 | 1200 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Binding affinity to cyclin-dependent kinase 1 (CDK1) | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibition of cyclin dependent kinase 1-cyclinB | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2000) 43: 1282-1292 [PMID:10753466] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of human cdk2/cyclin E | B | 8.05 | pIC50 | 9 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of human cdk2/cyclin A | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| ChEMBL | Inhibition of human CDK2/cyclinA using histone H1 as substrate incubated for 30 mins in presence of gamma[32P]ATP by phosphoimaging analysis | B | 7.3 | pIC50 | <50 | nM | IC50 | Eur J Med Chem (2016) 112: 298-346 [PMID:26907156] |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of Cyclin A-cyclin-dependent kinase 2 | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
| ChEMBL | Inhibition of Cyclin E-cyclin-dependent kinase 2 | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| GtoPdb | CDK4/cyclin D1 complex used in assay | - | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of Cyclin D1-cyclin-dependent kinase 4 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of human cdk4/cyclin D1 | B | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| GtoPdb | CDK5/p35 complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of human cdk5/p35 | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of recombinant CDK5/p35 (unknown origin) | B | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2022) 240: 114603-114603 [PMID:35868123] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of human GSK3-beta | B | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of human insulin receptor | B | 5.66 | pIC50 | 2200 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Inhibition of human Erk1 | B | 5.48 | pIC50 | 3333 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Inhibition of TrkA (unknown origin) by cell-based assay | B | 5.77 | pIC50 | 1710 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| ChEMBL | Inhibition of TrkA (unknown origin) | B | 7.29 | pIC50 | 51 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Inhibition of TrkB (unknown origin) by cell-based assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| ChEMBL | Inhibition of TrkB (unknown origin) | B | 7.96 | pIC50 | 11 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibition of human PKCalpha | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Inhibition of human PKCbeta1 | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of human PKCbeta2 | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Inhibition of human PKCdelta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Inhibition of human PKCepsilon | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
| ChEMBL | Inhibition of human PKCeta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| ChEMBL | Inhibition of human PKCgamma | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
| ChEMBL | Inhibition of human PKCzeta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
