ChEMBL ligand: CHEMBL3039502 (Copiktra, Duvelisib, Duvelisib hydrate, Duvelisib monohydrate, INK-1147, INK-1197, IPI-145)
phosphoinositide-3-kinase regulatory subunit 1/phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha/p85-alpha in Human [ChEMBL: CHEMBL2111367] [GtoPdb: 2503, 2153] [UniProtKB: P27986, P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p110-delta/p85-alpha in Human [ChEMBL: CHEMBL2111432] [GtoPdb: 2155, 2503] [UniProtKB: O00329, P27986] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!
phosphoinositide-3-kinase regulatory subunit 1/phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3K p110 beta/p85 alpha in Human [ChEMBL: CHEMBL3038510] [GtoPdb: 2503, 2154] [UniProtKB: P27986, P42338] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphoinositide-3-kinase regulatory subunit 1/phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha/p85-alpha in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111367] [GtoPdb: 2503, 2153] [UniProtKB: P27986, P42336]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 cells using phosphatidylinositol as substrate in presence of gamma-32P-ATP after 5 mins by thin layer chromatographic method	B	5	pIC50	<10000	nM	IC50	US-8193182-B2. Substituted isoquinolin-1(2H)-ones, and methods of use thereof (2012)
GtoPdb	-	-	5.8	pIC50	1602	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha (unknown origin)	B	5.8	pIC50	1602	nM	IC50	Eur J Med Chem (2019) 163: 413-427 [PMID:30530193]
GtoPdb	-	-	5.8	pIC50	1602	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb	-	-	7.07	pIC50	85	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
ChEMBL	Inhibition of PI3Kbeta (unknown origin)	B	7.07	pIC50	85	nM	IC50	Eur J Med Chem (2019) 163: 413-427 [PMID:30530193]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p110-delta/p85-alpha in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111432] [GtoPdb: 2155, 2503] [UniProtKB: O00329, P27986]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length p85alpha expressed in baculovirus infected Sf21 cells using phosphatidylinositol as substrate in presence of gamma-32P-ATP after 5 mins by thin layer chromatographic method	B	7	pIC50	<100	nM	IC50	US-8193182-B2. Substituted isoquinolin-1(2H)-ones, and methods of use thereof (2012)
GtoPdb	-	-	8.6	pIC50	2.5	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
ChEMBL	Inhibition of PI3KCdelta/PIK3R1 (unknown origin)	B	8.64	pIC50	2.3	nM	IC50	Eur J Med Chem (2018) 158: 405-413 [PMID:30237123]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay	B	9	pIC50	1	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of PI3Kdelta in human whole blood assessed as reduction in fMLP-stimulated CD63 expression in basophils preincubated for 30 mins followed by fMLP stimulation	B	5.66	pIC50	2206	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
ChEMBL	Inhibition of PI3Kdelta (unknown origin)	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2019) 163: 413-427 [PMID:30530193]
ChEMBL	Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgM-stimulated CD69 expression on B-cells preincubated for 60 mins followed by anti-IgM stimulation and measured after overnight incubation by flow cytometry	B	7.85	pIC50	14	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
GtoPdb	-	-	8.6	pIC50	2.5	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
ChEMBL	Inhibition of PI3Kdelta in human Raji cells	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (2019) 62: 4783-4814 [PMID:30582813]
ChEMBL	Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in antihuman IgM-stimulated AKT phosphorylation at Ser473 residue preincubated for 60 mins followed by antihuman IgM stimulation and measured after 15 mins	B	9	pIC50	1	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
ChEMBL	Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assay	B	9.3	pIC50	<0.5	nM	IC50	ACS Med Chem Lett (2016) 7: 908-912 [PMID:27774127]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL	Inhibition of recombinant human C-terminal His6-tagged p110gamma expressed in insect cells using phosphatidylinositol as substrate in presence of gamma-32P-ATP after 5 mins by thin layer chromatographic method	B	7	pIC50	<100	nM	IC50	US-8193182-B2. Substituted isoquinolin-1(2H)-ones, and methods of use thereof (2012)
ChEMBL	Inhibition of PI3Kgamma in human Raji cells	B	7.57	pIC50	27	nM	IC50	J Med Chem (2019) 62: 4783-4814 [PMID:30582813]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]
ChEMBL	Inhibition of PI3Kgamma in human whole blood assessed as reduction in anti-IgE-stimulated CD63 expression in basophils preincubated for 30 mins followed by anti-IgE stimulation	B	7.82	pIC50	15	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
ChEMBL	Inhibition of PI3KCgamma (unknown origin)	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2018) 158: 405-413 [PMID:30237123]
ChEMBL	Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assay	B	8.54	pIC50	2.9	nM	IC50	ACS Med Chem Lett (2016) 7: 908-912 [PMID:27774127]
ChEMBL	Inhibition of PI3Kgamma (unknown origin)	B	8.6	pIC50	2.5	nM	IC50	Eur J Med Chem (2019) 163: 413-427 [PMID:30530193]
ChEMBL	Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 80 mins by transcreener fluorescence polarization assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2019) 62: 4936-4948 [PMID:31033293]
phosphoinositide-3-kinase regulatory subunit 1/phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3K p110 beta/p85 alpha in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038510] [GtoPdb: 2503, 2154] [UniProtKB: P27986, P42338]
ChEMBL	Inhibition of N-terminal His6-tagged recombinant full-length human p110beta/untagged recombinant full length p85alpha expressed in baculovirus infected Sf21 cells using phosphatidylinositol as substrate in presence of gamma-32P-ATP after 5 mins by thin layer chromatographic method	B	6	pIC50	<1000	nM	IC50	US-8193182-B2. Substituted isoquinolin-1(2H)-ones, and methods of use thereof (2012)
GtoPdb	-	-	7.07	pIC50	85	nM	IC50	Chem Biol (2013) 20: 1364-74 [PMID:24211136]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]