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ChEMBL ligand: CHEMBL488817 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG | B | 5.42 | pIC50 | 3790 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
ChEMBL | Antagonist activity at human ERG by voltage-clamp electrophysiology assay | F | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
ChEMBL | Inhibition of sodium channel Nav1.5 by voltage-clamp method | B | 4.08 | pIC50 | 84000 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
ChEMBL | Inhibition of T-type calcium channel alpha1I by FLIPR | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]