TTA-P2 [Ligand Id: 7723] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL488817
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
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  • Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
  • Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
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  • Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
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  • Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 5.42 pIC50 3790 nM IC50 J Med Chem (2008) 51: 6471-6477 [PMID:18817368]
ChEMBL Antagonist activity at human ERG by voltage-clamp electrophysiology assay F 5.54 pIC50 2900 nM IC50 J Med Chem (2008) 51: 3692-3695 [PMID:18540666]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL Inhibition of sodium channel Nav1.5 by voltage-clamp method B 4.08 pIC50 84000 nM IC50 J Med Chem (2008) 51: 3692-3695 [PMID:18540666]
Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
ChEMBL Inhibition of T-type calcium channel alpha1I by FLIPR B 7.09 pIC50 82 nM IC50 J Med Chem (2008) 51: 6471-6477 [PMID:18817368]
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]
Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]