SB 714786 [Ligand Id: 77] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL425190
  • 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/5-hydroxytryptamine receptor 1D in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-ht1e receptor/5-hydroxytryptamine receptor 1E in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
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  • 5-HT1F receptor/5-hydroxytryptamine receptor 1F in Human [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
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  • 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT4 receptor/5-hydroxytryptamine receptor 4 in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
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  • 5-HT5A receptor/5-hydroxytryptamine receptor 5A in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
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  • 5-HT6 receptor/5-hydroxytryptamine receptor 6 in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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  • 5-HT7 receptor/5-hydroxytryptamine receptor 7 in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
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  • α1B-adrenoceptor/Alpha-1B adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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  • D2 receptor/D(2) dopamine receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • D3 receptor/D(3) dopamine receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor/D(4) dopamine receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • SERT/Sodium-dependent serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Displacement of [3H]WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cells B 6.5 pKi 316.23 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor B 6.5 pKi 316.23 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
GtoPdb - - 6.5 pKi - - - J Med Chem (2005) 48: 3478-80 [PMID:15887956]
5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells B 6.7 pKi 199.53 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]5HT from human recombinant 5HT1B receptor B 6.7 pKi 199.53 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
GtoPdb - - 6.7 pKi - - - J Med Chem (2005) 48: 3478-80 [PMID:15887956]
5-HT1D receptor/5-hydroxytryptamine receptor 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 9.1 pKi 0.79 nM Ki J Med Chem (2005) 48: 3478-80 [PMID:15887956]
ChEMBL Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells B 9.1 pKi 0.79 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]5HT from human recombinant 5HT1D receptor B 9.1 pKi 0.79 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
5-ht1e receptor/5-hydroxytryptamine receptor 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1E receptor B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT1F receptor/5-hydroxytryptamine receptor 1F in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1F receptor B 5.7 pKi 1995.26 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2A receptor B 5.6 pKi <2511.89 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2B receptor B 5.9 pKi 1258.93 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2C receptor B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT4 receptor/5-hydroxytryptamine receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Binding affinity for human 5-hydroxytryptamine 4 receptor B 5.3 pKi <5011.87 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT5A receptor/5-hydroxytryptamine receptor 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Binding affinity for human 5-hydroxytryptamine 5A receptor B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT6 receptor/5-hydroxytryptamine receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT7 receptor/5-hydroxytryptamine receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinity for human 5-hydroxytryptamine 7 receptor B 6.3 pKi 501.19 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
α1B-adrenoceptor/Alpha-1B adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Binding affinity for human alpha-1B adrenergic receptor B 6 pKi 1000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity for human beta-2 adrenergic receptor B 5.7 pKi 1995.26 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity for human dopamine receptor D2 B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D3 receptor/D(3) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity for human dopamine receptor D3 B 6 pKi 1000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D4 receptor/D(4) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity for human dopamine receptor D4 B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
SERT/Sodium-dependent serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of [3H]5-HT binding to serotonin transporter in rat cortical synaptosomes B 6.5 pKi 316.23 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Inhibition of [3H]5HT uptake at SERT in rat cortical synaptosomes B 6.5 pKi 316.23 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]