mirabegron [Ligand Id: 7445] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2095212 (Betanis, Betmiga, Mirabegron, Myrbetriq, Myrbetriq granules, YM-178, YM178) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| ChEMBL | Agonist activity at human beta-1 adrenoceptor expressed in CHO cells assessed as cAMP accumulation incubated for 10 mins by radioimmunoassay | F | 5 | pEC50 | >=10000 | nM | EC50 | Eur J Med Chem (2023) 250: 115172-115172 [PMID:36758304] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | >10000 | nM | EC50 | J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563] |
| ChEMBL | Agonist activity at human beta-2 adrenoceptor expressed in CHO cells assessed as cAMP accumulation incubated for 10 mins by radioimmunoassay | F | 5 | pEC50 | >=10000 | nM | EC50 | Eur J Med Chem (2023) 250: 115172-115172 [PMID:36758304] |
| GtoPdb | - | - | 5.2 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β2-adrenoceptor in Rat [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Agonist activity at human beta-3 adrenoceptor expressed in CHO cells assessed as cAMP accumulation incubated for 10 mins by radioimmunoassay | F | 7.65 | pEC50 | 22.4 | nM | EC50 | Eur J Med Chem (2023) 250: 115172-115172 [PMID:36758304] |
| GtoPdb | - | - | 8.8 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2007) 321: 642-7 [PMID:17293563]; Curr Ther Res Clin Exp (2022) 96: 100674 [PMID:35693456]; Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332]; Naunyn Schmiedebergs Arch Pharmacol (2013) 386: 247-53 [PMID:23239087] |
| β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962] | ||||||||
| GtoPdb | - | - | 7.8 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| GtoPdb | - | - | 9.3 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
| β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255] | ||||||||
| GtoPdb | - | - | 7.7 | pEC50 | - | - | - | Pharmacol Res Perspect (2020) 8: e00643 [PMID:32813332] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
